工业界感兴趣的一些化学反应

chem 化学亮点 4.7K+ 0

工业界感兴趣的一些化学反应  第1张


大家可以看一下工业界里面的研究者主要对学术界的哪些研究感兴趣。


1: The Minisci Reaction
Worthy of note is the fact that the procedure was successfully translated under photoflow conditions with a solvent shift to a 1:1 mixture of acetonitrile and DMA.

工业界感兴趣的一些化学反应  第2张


2: Cross-Ketonization
Worthy of note are the facts that prestirring without irradiation was found to be beneficial to improve yields by favoring activation prior to cross-coupling and that an excess of the acyl donor is used.

工业界感兴趣的一些化学反应  第3张



3: Direct Synthesis of α-Amino Acid
Access to enantioenriched compounds could be achieved via chirality transfer from pureEllman’s auxiliary with moderate to high enantiomeric excess.

工业界感兴趣的一些化学反应  第4张



4: Meta-Selective C−H Arylation of Phenols
To circumvent the typical reactivity pattern, this novel C−H arylation occurs via a Bi(V)-mediated electrophilic arylation to reach a disubstituted dienone intermediate. An aryl migration− rearomatization sequence then generates the final phenol product.

工业界感兴趣的一些化学反应  第5张



5: C4 Alkylation of Isoquinolines
The transformation is made possible by dearomatization using benzoic acid. Other acids were tested without improvements, although acetic acid also provides an acceptable alternative with lower yield.

工业界感兴趣的一些化学反应  第6张



6: C(sp2 )−C(sp3 ) Suzuki−Miyaura Cross-Coupling
Traditionally, this has achieved the kinds of palladium-mediated transformations that are commonly taught in undergraduate classes, but the use of such expensive raremetal catalysts has obvious drawbacks, particularly on scale.

工业界感兴趣的一些化学反应  第7张



7: current-controlled nickel-catalyzed multielectrophile electroreductive cross-coupling
Cross-electrophile coupling methodologies have seen an explosion of interest in recent years and are a favorite tool of medicinal chemists due to the huge number of commercially available aryl and alkyl bromides. Although these reactions are rarely run on scale, recent electrochemical methods have started to remove some of the disadvantages of earlier systems such as the use of a heterogeneous reductant or expensive HAT mediator.

工业界感兴趣的一些化学反应  第8张




8: site-selective electrochemical oxidation of glycosides
Traditionally, carbohydrate chemistry has been achieved through the dark art of protecting group chemistry, but in recent years significant progress has been made in the site-selective functionalizion of unprotected sugars.
Although the reaction can be driven by air rather than pure oxygen, the use of a flammable organic solvent under a noninert atmosphere as well as the high cost of quinuclidine may limit the usefulness of this method on scale.

工业界感兴趣的一些化学反应  第9张



9: photoinduced synthesis of functionalized oxacyclic spirooxindoles via ring expansion
stevens-type [1,2]-shift the protocol was demonstrated in flow on a gram scale and successfully exploited for the efficient synthesis of a reported pharmacologically active cb2 agonist.

工业界感兴趣的一些化学反应  第10张




10: intramolecular ring expansion of 3-silaazetidine with alkynes enabled by pd-catalyzed si−c bond activation

Switching a carbon atom for a silicon is emerging as a promising strategy for the discovery of novel bioactive substances showing benefits with regard to enhanced cell penetration, increased potency, and decreased toxicity.

工业界感兴趣的一些化学反应  第11张




11: palladium-catalyzed amination of base-sensitive five-membered heteroaryl halides with aliphatic amines

unproductive β-hydride elimination of the amine
Buchwald and coworkers reported a remarkably general system to facilitate these couplings that exploits the combination of a relativelymild base to slow decomposition of the heteroarene with asterically encumbered Pd catalyst to inhibit deactivation through coordination of the heterocycle.

工业界感兴趣的一些化学反应  第12张


12: piii/pv catalysis

Primary amination of aryl nucleophiles represents a valuable transformation, although it is limited to some degree by the documented safety concerns and/or availability of suitable H2N+ synthons.

工业界感兴趣的一些化学反应  第13张



13: meta c−h functionalization

和之前的一个反应几乎一模一样。

工业界感兴趣的一些化学反应  第14张



14: azadiene diels−alder reactions

However, while these reactions can often be carried out under milder conditions than conventional Diels−Alder reactions, efforts to catalyze such processes using Lewis acids have often failed due to preferential complexation and nonproductive consumption of the dienophile.

工业界感兴趣的一些化学反应  第15张


15: dual flow reactor

Flow chemistry tubular reactors, due to their short diameter (light path length), maximize incoming photon flux and enable the efficient scale-up of photochemical reactions.

工业界感兴趣的一些化学反应  第16张



16: ALKYLATION OF C(sp3 )−H BONDS

Primary amination of aryl nucleophiles represents a valuable transformation, although it is limited to some degree by the documented safety concerns and/or availability of suitable H2N+ synthons.

工业界感兴趣的一些化学反应  第17张



17: red-light-driven c−n cross-coupling

Dual nickel−photoredox-catalyzed Buchwald−Hartwig amination has been applied in industry by both medicinal chemists and process chemists. However, scalability issues arise when using blue or near-ultraviolet light due to its low penetration through reaction media.

工业界感兴趣的一些化学反应  第18张


18: peroxygenase catalyst

However, most enzymes catalyzing peroxygenation reactions make use of a cofactor and require nicotinamide cofactor (NAD(P)/H), which limits their use in preparative-scale applications.

工业界感兴趣的一些化学反应  第19张



19: semipinacol-driven dearomatization of pyridines

The less reactive Boc2O required at least 5 equiv to reach full conversion, limiting its practicality.

工业界感兴趣的一些化学反应  第20张



20: asymmetric total synthesis


工业界感兴趣的一些化学反应  第21张



21: late-stage c(sp3 )−h methylation

Mao and MacMillan reported the direct introduction of methyl groups via C(sp3 )−H functionalization of a broad array of saturated heterocycles enabled by the merger of decatungstate photocatalysis and a unique nickelmediated bimolecular homolytic substitution (SH2) bond formation.

工业界感兴趣的一些化学反应  第22张


发布评论 0条评论)

您需要 登录账户 后才能发表评论

还木有评论哦,快来抢沙发吧~