吲哚3位上氰基

chem 48884 0

吲哚3位上氰基

General Procedure for the Synthesis of 1H-Indole-3-carbonitriles

General procedure:

To a solution of the appropriate indoles 3a-d (6.8 mmol) in anhydrous acetonitrile (6.0 mL),chlorosulfonyl isocyanate (CSI) (0.63 mL, 7.25 mmol) was added dropwise at 0 °C and the reactionmixture was stirred at 0 °C for 2 h. Anhydrous dimethylformamide (DMF) (1.3 mL, 170.0 mmol)was added dropwise and the mixture was stirred at 0 °C for 2 h. The mixture was poured intoice-water and the obtained precipitate was filtered off, dried (anhydrous Na2SO4) and purified bycolumn chromatography using petroleum ether/ethyl acetate as eluent.

Ref:

Marine Drugs 2018,16, 274

标签: CSI

发布评论 0条评论)

您需要 登录账户 后才能发表评论

还木有评论哦,快来抢沙发吧~