除了利用DPPA和活性醇反应制备叠氮化物,现在又有了新方法!

chem 11280 0

利用DPPA通过Mitsunobu反应取代羟基合成叠氮化物的文章(点击: Mitsunobu反应合成叠氮化合物 ),但 Mitsunobu反应会生成大量的副产物,不易纯化。下面介绍一种可以得到相同产物的方法,利用DPPA和DBU,可以取代羟基得到构型翻转的叠氮化物,此反应生成副产物磷酸二苯酯和DBU盐都可以用水洗掉,可以很好的避免消除产物。但此反应,只对于活性醇(苄醇或羧酸α位羟基)效果较好。

除了利用DPPA和活性醇反应制备叠氮化物,现在又有了新方法!  第1张

反应机理

一、DPPA脱氧叠氮化机理:在DBU碱性条件下醇和DPPA反应得到磷酸酯,取代下来的DBU叠氮盐对磷酸酯进行SN2反应,构型翻转。

除了利用DPPA和活性醇反应制备叠氮化物,现在又有了新方法!  第2张

SulfoxFluor脱氧叠氮化机理:

除了利用DPPA和活性醇反应制备叠氮化物,现在又有了新方法!  第3张

General Procedure:A mixture of the alcohol (10 mmol) and diphenylphosphoryl azide (3.3 g, 12 mmol) were dissolved in dry solvent (18 ml). To the mixture at 0°C, under N2 was added neat l,8-diazabicyclo[5.4.0]undec-7-ene (1.8 ml, 12 mmol). The reaction was warmed to room temperature and stirred until complete. The resulting two phase mixture was washed with H2O (2 x 10 ml) and 5% HC1 (10 ml). The organic phase was concentrated in vacuo and purified by silica gel chromatography using 95:5(v:v) hexane: ethyl acetate.

除了利用DPPA和活性醇反应制备叠氮化物,现在又有了新方法!  第4张

(S)-(+)-ethyl lactate(2.54 g, 21.5 mmol) and DPPA (7 g, 25.4 mmol) were reacted with DBU (3.1 ml, 20.7 mmol) in THF (35 ml) at 20°C for 48 h. The batch was diluted with 5:1 hexane:ethyl acetate (120 ml) and washed with H2 O (2 x 40 ml) and 5% HC1 (40 ml). The yield by HPLC assay was 87%. HPLC conditions [CH3CN:H2 0 gradient elution from 50:50 to 70:30 in 15 min,

flow =1.5 ml/min, U.V.detection at 210 nm] tR 4„5 min. The batch was concentrated and distilled to afford 2.2 gm (72%) of the volatile azide.

参考文献

J. Org. Chem.199358(22), pp 5886–5888

发布评论 0条评论)

您需要 登录账户 后才能发表评论

还木有评论哦,快来抢沙发吧~