Valent titanium Reductive Cleavage of Sulfonamides and Sulfonates

A low-valent titanium generated in situ from Ti(O-i-Pr)₄, Me₃SiCl, and Mg powder in THF reacted with aryl- and alkyl-sulfonamides of aryl and alkyl amines in a reductive N–S/S–O/S–C bond cleaving pathway to provide the corresponding amines and hydrocarbons (and thiols) derived from the sulfonyl moiety. The reagent could also cleave sulfonates to the corresponding alcohols.

Ti(O-i-Pr)4Me3SiClMg-Mediated Reductive Cleavage of Sulfonamides and Sulfonates to Amines and Alcohols.pdf

Org. Lett., 2011, 13 (10), pp 2626–2629

https://pubs.acs.org/doi/abs/10.1021/ol200740r

标签： Sulfonamide