Cu-Mediated Chemoselective Trifluoromethylation of Benzyl Bromides

Copper-mediated chemoselective trifluoromethylation at the benzylic position by the use of shelf-stable electrophilic trifluoromethylating reagents 3 in good to high yields under mild conditions is described for the first time. The generality of this trifluoromethylation for a wide variety of benzyl bromides facilitates the rapid creation of structural diversity of medicinal candidates in drug discovery.

https://pubs.acs.org/doi/abs/10.1021/ol201205t

标签： 三氟甲基