A solution ofN-(4-chlorobenzyl)-4-hydroxy-6-iodo-3-quinolinecarboxamide (30.0 g), Et3N(19.1 mL), MeOH (110.6 mL), Pd(OAc)2 (431 mg), and1,3-bis(diphenylphosphino)propane (791.9 mg) in 375 mL anhydrous DMF is stirredat room temperature until everything dissolves. The mixture is purgedby carbon monoxide at room temperature for 10 minutes, then is heated at 90 oCand stirred overnight under 40 psi of carbon monoxide.Thereaction is cooled to room temperature. The product is precipitated by adding160 mL 1 N HCl into the reaction mixture. An orange solid precipitates iscollected. The solid is triturated with EtOAc, filtered, and washed with CH2Cl2to afford 23.8 g (93 % yield) of the title compound as an off-white solid.